TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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In vitro production of monoclonal antibodies (hybridoma technique)
TM Status: Closed
Test Method Number: TM1998-04 (EU)
Short Name of TM: In vitro mAbs
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Human health
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Genomic Embryonic Stem cell Test method
TM Status: Closed
Test Method Number: TM2012-04 (EU)
Short Name of TM: gEST
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
Embryotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Cell Transformation Assay Based on the Bhas 42 Cell Line
TM Status: Closed
Test Method Number: TM2012-06 (EU)
Short Name of TM: Bhas 42 CTA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Carcinogenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Syrian hamster embryo cell transformation assay at pH 6.7
TM Status: Closed
Test Method Number: TM2005-02 (EU)
Short Name of TM: SHE 6.7 CTA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Carcinogenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Syrian hamster embryo cell transformation assay at pH 7.0
TM Status: Closed
Test Method Number: TM2005-03 (EU)
Short Name of TM: SHE 7.0 CTA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Carcinogenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards