TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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GreenScreen HC TM Genotoxicity Assay
TM Status: Closed
Test Method Number: TM2009-08 (EU)
Short Name of TM: Greenscreen
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Genotoxicity/Mutagenicity
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Human Reconstructed Corneal Epithelium (HCE) Eye Irritation test
TM Status: Closed
Test Method Number: TM2008-09 (EU)
Short Name of TM: SkinEthic HCE
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
LuSens Assay
TM Status: Closed
Test Method Number: TM2011-10 (EU)
Short Name of TM: LuSens
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Skin Irritation Test for the Prediction of Acute Skin Irritation of Chemicals With Sterlab RHE: 42 minutes application + 42 hours post-incubation
TM Status: Closed
Test Method Number: TM2014-06 (EU)
Short Name of TM: Sterlab RHE SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Direct Peptide Reactivity Assay
TM Status: Closed
Test Method Number: TM2009-06 (EU)
Short Name of TM: DPRA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
  •  
    Regulatory acceptance/Standards