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Bioaccessibility testing (Bioelution) of metals, inorganic metals compounds and metals-containing materials: simulated gastric fluid

Test Method Number: TM2016-02 (EU)
Short Name of TM: Bioelution
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Bioaccessibility
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Transcriptional activation assay for detection of androgenic activity of chemicals

Test Method Number: TM2010-07 (EU)
Short Name of TM: AR-CALUX
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Reproductive toxicity, Endocrine disruption
General Comments:

The AR-CALUX method was submitted by BioDetection Systems (The Netherlands) for a EURL ECVAM coordinated validation study.  The experimental part was concluded by the end of 2018 and the report reviewed by ESAC in June 2019.  The draft TG (TG458) was submitted to OECD mid June 2019, for commenting rounds to start at WNT.  The TG458 was adopted (April 2020) and published(June 2020).  This TG includes 3 validated ARTA methods: AR-EcoScreen from Japan, AR-CALUX from the Netherlands, 22Rv1/MMTV_GR-KO assay from Korea.
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Genomic Allergen Rapid Detection test

Test Method Number: TM2011-09 (EU)
Short Name of TM: GARD
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Sensitisation
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Ocular Irritection

Test Method Number: TM2006-02 (EU)
Short Name of TM: Ocular Irritection
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Serious eye damage/Eye irritation
Protocol(s)/SOP(s): 157
General Comments:

Revised Test Submission Template on the Ocular Irritection® test method proposed for Peer Review
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Rat skin transcutaneous electrical resistance test

Test Method Number: TM1995-01 (EU)
Short Name of TM: TER
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Skin Corrosion
Protocol(s)/SOP(s): 115
General Comments:
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Reconstructed Human Epidermis Model Test

Test Method Number: TM2005-04 (EU)
Short Name of TM: EpiSkin™ - RHE
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Skin irritation
Protocol(s)/SOP(s): 131
General Comments:
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Cytochrome P450 (CYP) enzyme induction in vitro method using cryopreserved differentiated human HepaRG™ cells

Test Method Number: TM2009-14 (EU)
Short Name of TM: HepaRG™
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Toxicokinetics
Protocol(s)/SOP(s): 194
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Cytochrome P450 (CYP) enzyme induction in vitro method using the cryopreserved human hepatocytes

Test Method Number: TM2009-13 (EU)
Short Name of TM: CryoHeps
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Toxicokinetics
Protocol(s)/SOP(s): 193
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Epidermal Skin Corrosion Test 1000

Test Method Number: TM2007-01 (EU)
Short Name of TM: Epics SCT
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Skin Corrosion
General Comments:
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

The Colony Forming Unit-Granulocyte/Macrophage Assay for predicting acute neutropenia in humans

Test Method Number: TM2000-01 (EU)
Short Name of TM: CFU-GM
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Acute toxicity
Protocol(s)/SOP(s): 101
General Comments:
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

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