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Thyroid method 1a: PATHHUNTER® BETA-ARRESTIN thyrotropin-releasing hormone (TRH) receptor activation (beta-galactosidase) measuring agonist and antagonist activities

TM Status: Open
Test Method Number: TM2019-02 (EU)
Short Name of TM: TRH-CHOK1
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 1b: Thyrotropin-stimulating hormone (TSH) receptor activation based on cAMP measurement

TM Status: Open
Test Method Number: TM2019-03 (EU)
Short Name of TM: TSH-CHOK1
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 2a: Thyroperoxidase (TPO) inhibition based on oxidation of Amplex UltraRed

TM Status: Open
Test Method Number: TM2019-04 (EU)
Short Name of TM: AUR-TPO
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 2b: Thyroperoxidase (TPO) inhibition based on oxidation of Luminol

TM Status: Open
Test Method Number: TM2019-05 (EU)
Short Name of TM: TPO-LUM
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 2c: Tyrosine iodination using liquid chromatography

TM Status: Open
Test Method Number: TM2019-06 (EU)
Short Name of TM: TYRO-IOD
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 2d: Activation of the sodium iodide symporter (NIS) based on Sandell-Kolthoff reaction

TM Status: Open
Test Method Number: TM2019-07 (EU)
Short Name of TM: NIS-SKR
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 3a: Thyroxine-binding prealbumin (TTR) / thyroxine-binding globulin (TBG) binding using fluorescence displacement (ANSA)

TM Status: Open
Test Method Number: TM2019-08 (EU)
Short Name of TM: ANSA-FD
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 3b: Thyroxine-binding prealbumin (TTR) binding using fluorescence displacement (T4-FITC)

TM Status: Open
Test Method Number: TM2019-09 (EU)
Short Name of TM: T4-FITC
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 4a: Deiodinase 1 activity based on Sandell-Kolthoff reaction

TM Status: Open
Test Method Number: TM2019-10 (EU)
Short Name of TM: DIO1-SKR
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards

Thyroid method 4b: Inhibition of thyroid hormones (THs) glucuronidation using liquid chromatography/mass spectrometry (LC/MS)

TM Status: Open
Test Method Number: TM2019-11 (EU)
Short Name of TM: GLUC-LCMS
Responsible Organisation: EURL ECVAM - European Union '
Topic(s):Endocrine disruption
  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards