TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

Results 126 - 130 of 146
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3T3 Neutral Red Uptake cytotoxicity assay
TM Status: Closed
Test Method Number: TM2007-03 (EU)
Short Name of TM: 3T3 NRU
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Acute toxicity,
Basal Cytotoxicity
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    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Neutral red uptake for starting doses for acute oral toxicity
TM Status: Closed
Test Method Number: TM2003-01 (US)
Short Name of TM: NRU cytotoxicity
Responsible Organisation: ICCVAM/NICEATM - United States 
Topic(s): Acute toxicity,
Basal Cytotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
KeratinoSens assay for the testing of skin sensitizers
TM Status: Closed
Test Method Number: TM2010-03 (EU)
Short Name of TM: KeratinoSens
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
H2AX ICW method, gH2AX In cell western
TM Status: Closed
Test Method Number: TM2014-02 (EU)
Short Name of TM: H2AX ICW
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Genotoxicity/Mutagenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
gH2AX/pH3 biomarkers for the prediction of DNA damage
TM Status: Closed
Test Method Number: TM2017-01 (EU)
Short Name of TM: gH2AX/pH3
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Genotoxicity/Mutagenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards