TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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The IMOLA-IVD test method for eye irritation testing
TM Status: Closed
Test Method Number: TM2010-04 (EU)
Short Name of TM: IMOLA-IVD
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
THOR VitroDerm RhE test method for skin irritation testing
TM Status: Closed
Test Method Number: TM2009-10 (EU)
Short Name of TM: VitroDerm
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
In vitro Method for Identifying Skin Sensitisers Combining Peptide Binding with ARE/EpRE Mediated Gene Expression in Human Skin Cells
TM Status: Closed
Test Method Number: TM2011-02 (EU)
Short Name of TM: SenCeetox
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
RHE IL-18 potency test for skin sensitization
TM Status: Closed
Test Method Number: TM2012-05 (EU)
Short Name of TM: RHE IL-18
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Skin absorption based on RHE models
TM Status: Closed
Test Method Number: TM2008-13 (EU)
Short Name of TM: Skin absorption RHE
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin absorption/penetration
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards