TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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LabCyte EPI-MODEL24 skin corrosion test
TM Status: Closed
Test Method Number: TM2017-03 (JAP)
Short Name of TM: LabCyte EPI-MODEL24 SCT
Responsible Organisation: JaCVAM - Japan
Topic(s): Skin Corrosion
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
LabCyteCORNEAMODEL24 eye irritation test
TM Status: Closed
Test Method Number: TM2015-04 (JAP)
Short Name of TM: LabCyteCORNEAMODEL24 EIT
Responsible Organisation: JaCVAM - Japan
Topic(s): Serious eye damage/Eye irritation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 2b: Thyroperoxidase (TPO) inhibition based on oxidation of Luminol
TM Status: Closed
Test Method Number: TM2019-05 (EU)
Short Name of TM: TPO-LUM
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
In vitro model for the prediction of respiratory sensitization of inhalable substances
TM Status: Closed
Test Method Number: TM2019-01 (EU)
Short Name of TM: ALIsens
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Two-tiered approach to determine the skin sensitising capacity and potency of chemicals
TM Status: Closed
Test Method Number: TM2011-12 (EU)
Short Name of TM: 2-TA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards