TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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Multiplexed SRM (Selected Reaction Monitoring) Mass Spectrometric Assays for Targeted Quantification of Skin Sensitization Biomarkers in Dendritic Cell Models
TM Status: Closed
Test Method Number: TM2011-08 (EU)
Short Name of TM: DC-SRM
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Sensitisation
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
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    Regulatory acceptance/Standards
Bovine Oocyte Maturation Assay
TM Status: Closed
Test Method Number: TM2010-05 (EU)
Short Name of TM: IVM
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
In vitro fertilisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Skinethic Skin Irritation Test-42bis
TM Status: Closed
Test Method Number: TM2008-02 (EU)
Short Name of TM: SkinEthic RHE
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Modified EpiDerm Skin Irritation Test for Hazard Identification and Labelling of Chemicals According to EU Classification System
TM Status: Closed
Test Method Number: TM2008-01 (EU)
Short Name of TM: Modified EpiDerm SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
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    Submission
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    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Ocular Irritection
TM Status: Closed
Test Method Number: TM2006-02 (EU)
Short Name of TM: Ocular Irritection
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
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    Submission
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    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards