TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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Blood-brain barrier-on-a-chip (BBB-oC) for drug testing of brain-targeting delivery
TM Status: Closed
Test Method Number: TM2024-01 (EU)
Short Name of TM: BBB-oC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Human health
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    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Bioaccessibility testing (Bioelution) of metals, inorganic metals compounds and metals-containing materials: simulated gastric fluid
TM Status: Closed
Test Method Number: TM2016-02 (EU)
Short Name of TM: Bioelution
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Bioaccessibility
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Epidermal Sensitization Assay
TM Status: Closed
Test Method Number: TM2018-01 (JAP)
Short Name of TM: EpiSensA
Responsible Organisation: JaCVAM - Japan
Topic(s): Skin sensitisation
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
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    Regulatory acceptance/Standards
Androgen Receptor Transactivation Assay for Detection of androgenic Agonist and Antagonist Activity of Chemicals using the stably transfected human 22Rv1/MMTV_GR-KO cell line
TM Status: Closed
Test Method Number: TM2020-02 (OECD)
Short Name of TM: 22Rv1/MMTV_GR-KO
Responsible Organisation: OECD - International Organisation
Topic(s): Endocrine disruption
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
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    Regulatory acceptance/Standards
The The VM7Luc ER TA test method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals
TM Status: Closed
Test Method Number: TM2016-09 (US)
Short Name of TM: VM7Luc ER TA
Responsible Organisation: ICCVAM/NICEATM - United States 
Topic(s): Reproductive toxicity,
Endocrine disruption
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards