TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM). 

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer.

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Thyroid method 2a: Thyroperoxidase (TPO) inhibition based on oxidation of Amplex UltraRed
TM Status: Closed
Test Method Number: TM2019-04 (EU)
Short Name of TM: AUR-TPO
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
  •  
    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 1a: PATHHUNTER® BETA-ARRESTIN thyrotropin-releasing hormone (TRH) receptor activation (beta-galactosidase) measuring agonist and antagonist activities
TM Status: Closed
Test Method Number: TM2019-02 (EU)
Short Name of TM: TRH-CHOK1
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
GARDskin Dose-Response
TM Status: Open
Test Method Number: TM2025-01 (EU)
Short Name of TM: GARDSkin DR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Blood-brain barrier-on-a-chip (BBB-oC) for drug testing of brain-targeting delivery
TM Status: Closed
Test Method Number: TM2024-01 (EU)
Short Name of TM: BBB-oC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Human health
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Bioaccessibility testing (Bioelution) of metals, inorganic metals compounds and metals-containing materials: simulated gastric fluid
TM Status: Closed
Test Method Number: TM2016-02 (EU)
Short Name of TM: Bioelution
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Bioaccessibility
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards