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Rat recombinant androgen receptor binding assay for the detection of compounds with (anti)androgenic potential

Test Method Number: TM2010-01 (EU)
Short Name of TM: ARBA
Responsible Organisation: EURL ECVAM - European Union
General Comments:

Not prioritised for validation by ECVAM

Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Transactivation assay for detection of compounds with (anti)androgenic potential using PALM cells

Test Method Number: TM2010-02 (EU)
Short Name of TM: PALM cell assay
Responsible Organisation: EURL ECVAM - European Union
General Comments:

Not prioritised for validation by ECVAM due to issues regarding the material transfer agreement

Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The ToxCast Estrogen Receptor Agonist Pathway Model

Test Method Number: TM2016-08 (US)
Short Name of TM: ToxCast ER Pathway Model
Responsible Organisation: ICCVAM/NICEATM - United States
General Comments:
Stage of Submission: Assessment Finalised
Stage of Validation: Finalised
Stage of Peer-review: Finalised
Stage of Recommendation: Published
Stage of Regulatory acceptance/Standards: Adopted
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The LUMI-CELLĀ® ER Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals

Test Method Number: TM2016-09 (US)
Short Name of TM: VM7Luc ER TA
Responsible Organisation: ICCVAM/NICEATM - United States
General Comments: This test method was originally referred to as the BG1Luc ER TA method.
Stage of Submission: Assessment Finalised
Stage of Validation: Finalised
Stage of Peer-review: Finalised
Stage of Recommendation: Published
Stage of Regulatory acceptance/Standards: Adopted
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Chemical reactivity measurement using the gluthatione (GSH and GSSG) peptide binding HPLC assay

Test Method Number: TM2009-04 (EU)
Short Name of TM: GSH-GSSG
Responsible Organisation: EURL ECVAM - European Union
General Comments:

Not prioritised for validation by ECVAM. In the context of the Cosmetics Europe/EURL ECVAM Eye Irritation Validation Study it was decided in April 2009 not to include the GSH/GSSG reactivity assay in the SkinEthicTM HCE test strategy.

Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Chemical reactivity measurement using the cysteine or lysine peptide binding HPLC assay

Test Method Number: TM2009-03 (EU)
Short Name of TM: EPRA
Responsible Organisation: EURL ECVAM - European Union
General Comments:

Validation performed in context of the Cosmetics Europe/EURL ECVAM Eye Irritation Validation Study in the scope of the validation of SkinEthic HCE (TM2008-09)

Stage of Submission: Assessment Finalised
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Automated screening to detect cardiotoxicity in zebrafish

Test Method Number: TM2009-07 (EU)
Short Name of TM: Zebrafish assay
Responsible Organisation: EURL ECVAM - European Union
General Comments:

On hold-pending further information

Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The IMOLA-IVD test method for eye irritation testing

Test Method Number: TM2010-04 (EU)
Short Name of TM: IMOLA-IVD
Responsible Organisation: EURL ECVAM - European Union
General Comments:

On hold-pending further information

Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The Electrophilic Allergen Screening Assay for the Detection of Substances Causing Allergic Contact Dermatitis

Test Method Number: TM2016-07 (US)
Short Name of TM: EASA
Responsible Organisation: ICCVAM/NICEATM - United States
General Comments:
Stage of Submission: Assessment Finalised
Stage of Validation: Planning
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Human Reconstructed Corneal Epithelium (HCE) Eye Irritation test

Test Method Number: TM2008-09 (EU)
Short Name of TM: SkinEthic HCE
Responsible Organisation: EURL ECVAM - European Union
General Comments:

This test method was unable to comply fully with the acceptance criteria set by the validation management group. A revised SkinEthic™ HCE EIT test method was re-submitted for assessment by EURL ECVAM and formal ESAC peer review in October 2015 (See TM2015-03, SkinEthic-HCE-EIT).

Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards