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The ToxCast Estrogen Receptor Agonist Pathway Model

Topic : Reproductive toxicity, Endocrine disruption

Test Method Number: TM2016-08 (US)
Short Name of TM: ToxCast ER Pathway Model
Year received: 2016
Responsible Organisation: ICCVAM/NICEATM - United States '
General Comments:

Method Description

The ToxCast estrogen receptor (ER) pathway model is a mathematical model that combines the results from 18 high-throughput screening (HTS) assays from the ToxCast and Tox21 research programs. The HTS assays measure ER binding, dimerization, chromatin binding, transcriptional activation and ER-dependent cell proliferation. The model uses activity patterns across the in vitro assays to predict whether a chemical is an ER agonist or antagonist, or is otherwise influencing the assays through a manner dependent on the physics and chemistry of the technology platform (“assay interference”). The output of the model provides an area under the curve (AUC) value for the potential of a chemical to cause ER agonism, normalized with respect to the positive control chemical, estradiol.

Track Approval Status

  • Submission
  • Validation
  • Peer-review
  • Recommendation
  • Regulatory acceptance/Standards
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