TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

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devTOX qp (Stemina) devTOX quick Predict
TM Status: Closed
Test Method Number: TM2014-04 (EU)
Short Name of TM: devTOXqP
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Teratogenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Light Up Cell Systems
TM Status: Closed
Test Method Number: TM2014-05 (EU)
Short Name of TM: LUCS
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Acute toxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
gH2AX/pH3 biomarkers for the prediction of DNA damage
TM Status: Closed
Test Method Number: TM2017-01 (EU)
Short Name of TM: gH2AX/pH3
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Genotoxicity/Mutagenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
SkinEthic™ HCE Eye Irritation Test
TM Status: Closed
Test Method Number: TM2015-03 (EU)
Short Name of TM: SkinEthic HCE EIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Bioaccessibility testing (Bioelution) of metals, inorganic metals compounds and metals-containing materials: simulated gastric fluid
TM Status: Open
Test Method Number: TM2016-02 (EU)
Short Name of TM: Bioelution
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Bioaccessibility
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
ToxTracker Assay
TM Status: Open
Test Method Number: TM2016-03 (EU)
Short Name of TM: ToxTracker
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Genotoxicity/Mutagenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Predictive testing for adverse psychiatric side effects
TM Status: Open
Test Method Number: TM2016-01 (EU)
Short Name of TM: EDITOX
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Neurotoxicity,
Human health
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
A new in vitro eye irritation test with a 3D-reconstructed human cornea epithelium, MCTT HCE™
TM Status: Open
Test Method Number: TM2016-04 (KOR)
Short Name of TM: MCTT HCE™-EIT
Responsible Organisation: KoCVAM - Republic of Korea
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Hen’s Egg Test – Chorio-Allantoic Membrane
TM Status: Open
Test Method Number: TM2016-05 (BRA)
Short Name of TM: HET-CAM
Responsible Organisation: BraCVAM - Brazil 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Monocyte Activation Test
TM Status: Open
Test Method Number: TM2016-06 (BRA)
Short Name of TM: MAT
Responsible Organisation: BraCVAM - Brazil 
Topic(s): Quality control of vaccines,
Airborne pyrogens
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards