TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE
TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

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Thyroid method 2d: Activation of the sodium iodide symporter (NIS) based on Sandell-Kolthoff reaction
TM Status: Open
Test Method Number: TM2019-07 (EU)
Short Name of TM: NIS-SKR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 3b: Thyroxine-binding prealbumin (TTR) binding using fluorescence displacement (T4-FITC)
TM Status: Open
Test Method Number: TM2019-09 (EU)
Short Name of TM: T4-FITC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Quantitative prediction of inflammation from acute to chronic condition associated with inhalation and delivered ahead of time by lung animal-free in-vitro-learned digital twin (InFiniteLungDT)
TM Status: Open
Test Method Number: TM2025-02 (EU)
Short Name of TM: InFiniteLungDT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Human Health Effects
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 8a: Measurement of proliferation of rat pituitary-derived cell line GH3
TM Status: Open
Test Method Number: TM2019-17 (EU)
Short Name of TM: T-SCREEN
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
GARDskin Dose-Response
TM Status: Open
Test Method Number: TM2025-01 (EU)
Short Name of TM: GARDSkin DR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards