TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer.

Results 1 - 10 of 10
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The 3T3 neutral red uptake (NRU) phototoxicity assay
TM Status: Closed
Test Method Number: TM1994-01 (EU)
Short Name of TM: 3T3NRU Phototoxicity
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Ros (Reactive Oxygen Species) Assay for Photoreactivity
TM Status: Closed
Test Method Number: TM2013-04 (JAP)
Short Name of TM: Ros Assay
Responsible Organisation: JaCVAM - Japan
Topic(s): Skin irritation,
Skin sensitisation,
Genotoxicity/Mutagenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
LabCyte EPI-MODEL24 skin irritation test
TM Status: Closed
Test Method Number: TM2008-14 (JAP)
Short Name of TM: LabCyte EPI-MODEL24 SIT
Responsible Organisation: JaCVAM - Japan
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
THOR VitroDerm RhE test method for skin irritation testing
TM Status: Closed
Test Method Number: TM2009-10 (EU)
Short Name of TM: VitroDerm
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Skinethic Skin Irritation Test-42bis
TM Status: Closed
Test Method Number: TM2008-02 (EU)
Short Name of TM: SkinEthic RHE
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Modified EpiDerm Skin Irritation Test for Hazard Identification and Labelling of Chemicals According to EU Classification System
TM Status: Closed
Test Method Number: TM2008-01 (EU)
Short Name of TM: Modified EpiDerm SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Reconstructed Human Epidermis Model Test
TM Status: Closed
Test Method Number: TM2005-04 (EU)
Short Name of TM: EpiSkin™ - RHE
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Ashland Skin Irritation Test
TM Status: Closed
Test Method Number: TM2015-02 (EU)
Short Name of TM: Ashland RhE SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
epiCS Skin Irritation Test
TM Status: Closed
Test Method Number: TM2009-09 (EU)
Short Name of TM: epiCS SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Skin Irritation Test for the Prediction of Acute Skin Irritation of Chemicals With Sterlab RHE: 42 minutes application + 42 hours post-incubation
TM Status: Closed
Test Method Number: TM2014-06 (EU)
Short Name of TM: Sterlab RHE SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards