TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

Note that TSAR includes only the methods that have been validated by governmental organisations affiliated with the International Cooperation on Alternative Test Methods (ICATM).

Furthermore, the documentation included in the TSAR database are the versions that were used during the validation of the respective test methods. These documents are provided for reference and transparency purposes only and may not correspond to the most up-to-date versions currently in use, nor can it be excluded that additional documentation exists. For the latest SOPs and technical information, users should contact the relevant test method developer. 

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Red Blood Cell haemolysis
TM Status: Closed
Test Method Number: TM2004-04 (EU)
Short Name of TM: RBC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Neutral Red Release Assay
TM Status: Closed
Test Method Number: TM2004-03 (EU)
Short Name of TM: NRR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Myeloid U937 Skin Sensitisation Test
TM Status: Closed
Test Method Number: TM2009-05 (EU)
Short Name of TM: MUSST
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Prediction of the in vivo estrogenic activity of chemicals ERalpha-CALUX
TM Status: Closed
Test Method Number: TM2009-11 (EU)
Short Name of TM: ERalpha-CALUX
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
Endocrine disruption
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
The cytosensor microphysiometer toxicity test
TM Status: Closed
Test Method Number: TM2004-01 (EU)
Short Name of TM: Cytosensor
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards