iPSC-derived corneal epithelial cells for ocular toxicity tests

Topic: Serious eye damage/Eye irritation

Test Method Number:

TM2014-07 (EU)

Short Name of TM:

CORNiPSC

Year received:

2014

Responsible Organisation:

EURL ECVAM - European Union

General Comments:

Not considered for follow-up

Method Description

The CORNiPSC is intended to be used for eye irritation testing. It is an in vitro method that applies corneal epithelial cells produced from human induced pluripotent stem cell (iPSC) lines and grown in a two-dimensional cell culture. The endpoint measurement is done by determination of cell viability.

This test method is in a presubmission stage. Further refinement of the testing protocol in the light of the addressed key endpoint, will show, if this test method could be useful in the initial step of either a Bottom-Up or a Top-Down approach to be used in an integrated testing strategy.

Track Approval Status

Submission
Validation
Peer-review
Recommendation
Regulatory acceptance/Standards

Submission

Show status

Date	Stage	Comment	Documents/Links
Dec 2014	Receipt of presubmission	Test presubmission received.
May 2015	Stopped	Submitter notified of presubmission outcome. Method not considered for follow-up.

Validation

Peer-review

Recommendation

Regulatory acceptance/Standards