Apr 1998 |
Assessment finalised |
ICCVAM evaluated an LLNA submission from Proctor & Gamble that included LLNA publications and the results of several European validation studies. |
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Apr 1998 |
Finalised |
ICCVAM conducted a review of LLNA performance in the Proctor & Gamble submission containing published literature and results of European validation studies and recommended it as an alternative to guinea pig tests for assessing the allergic potential of chemicals to cause ACD. |
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Mar 2009 |
Finalised |
ICCVAM, in conjunction with ECVAM and JaCVam, developed harmonized performance standards (PS) for the LLNA, based on performance of the LLNA compared to results from guinea pig tests and human outcomes, that could be used to evaluate modified versions of the LLNA. The PS's included essential test method components, a miminum list of reference substances, and standards for accuracy and reliability. |
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Mar 2010 |
Published |
ICCVAM/NICEATM published a test method evaluation report on the murine LLNA: BrdU-ELISA, A nonradioactive alternative test method to assess the ACD potential of chemicals and products and concluded that the accuracy and reliability of the test method support its use to identify substances as potential skin sensitizers or nonsensitizers. |
ICCVAM Test Method Evaluation Report on the Murine LLNA:BrdU-ELISA, a Nonradioactive Alternative Test Method to Assess the ACD Potential of Chemicals and Products |
Mar 2010 |
Published |
ICCVAM/NICEATM published a Test Method Evaluation Report on the Murine LLNA: DA (test method developed by Daicel Chemical Industries, Ltd. in Hyogo, Japan that measures ATP content as an indicator of lymphocyte proliferation), a Nonradioactive Alternative Test Method to Assess the ACD Potential of Chemicals and Products and concluded that the accuracy and reliability of the test method support its use to identify potential skin sensitizers and nonsensitizers. |
ICCVAM Test Method Evaluation Report on the Murine LLLNA: DA, a Nonradioactive Test Method to Assess the ACD Potential of Chemicals and Products |
Jun 2011 |
Published |
ICCVAM evaluated the usefulness and limitations of the murine LLNA for potency categorization of chemicals causing allergic contact dermatitis in humans and concluded that the LLNA can be used to categorize substances as strong sensitizers using the GHS Subcategory 1A, when the estimated concentration that produces a positive LLNA result (i.e., EC3) is <=2%, but additional information is needed for Subcategory 1B, when the substance produces an LLNA EC3 >2%. |
ICCVAM Test Method Evaluation Report: Usefulness and Limitations of the Murine LLNA for Potency Categorization of Chemicals Causing ACD in Humans |
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