Rat skin transcutaneous electrical resistance test

Method Description

The assay is based on determining the effects of a chemical on the electrical resistance of rat skin (i.e. TER). A second endpoint is the ability of a dye to penetrate through rat skin following exposure to a chemical.
The test can be used to identify potential corrosive chemicals or mixtures. It can also be used to identify chemicals that are non-corrosive when used in combination with other methods.
Evidence indicates that TER measurements are predictive of severe cutaneous effects in vivo. The (later) addition of the dye to the test reduces false positives.