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A new in vitro eye irritation test with a 3D-reconstructed human cornea epithelium, MCTT HCE™

Test Method Number: TM2016-04 (KOR)
Short Name of TM: MCTT HCE™-EIT
Responsible Organisation: KoCVAM - Republic of Korea
Stage of Submission: Assessment Finalised
Stage of Validation: Ongoing
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Hen’s Egg Test – Chorio-Allantoic Membrane

Test Method Number: TM2016-05 (BRA)
Short Name of TM: HET-CAM
Responsible Organisation: BraCVAM - Brazil
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

In vitro aproach for organophosphorous compounds-induced neurotoxicity (OP Neurotox Assay)

Test Method Number: TM2009-12 (EU)
Short Name of TM: OPIV
Responsible Organisation: EURL ECVAM - European Union
General Comments: Not prioritised for validation by ECVAM because it did not fulfilled ECVAM criteria.
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

In vitro sensitisation testing strategy

Test Method Number: TM2011-14 (EU)
Short Name of TM: In vitro STS
Responsible Organisation: EURL ECVAM - European Union
General Comments: Not considered for follow-up, skin sensitisation IATAs are currently being addressed in the OECD Task Force on Hazard Assessment
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Monocyte Activation Test

Test Method Number: TM2016-06 (BRA)
Short Name of TM: MAT
Responsible Organisation: BraCVAM - Brazil
Stage of Validation: Ongoing
Stage of Regulatory acceptance/Standards: Drafting of new regulatory standard/guideline
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Multiplexed SRM (Selected Reaction Monitoring) Mass Spectrometric Assays for Targeted Quantification of Skin Sensitization Biomarkers in Dendritic Cell Models

Test Method Number: TM2011-08 (EU)
Short Name of TM: DC-SRM
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

RHE IL-18 potency test for skin sensitization

Test Method Number: TM2012-05 (EU)
Short Name of TM: RHE IL-18
Responsible Organisation: EURL ECVAM - European Union
General Comments: Invitation to send a full submission
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

THOR VitroDerm RhE test method for skin irritation testing

Test Method Number: TM2009-10 (EU)
Short Name of TM: VitroDerm
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Transcriptomics based Genomics-Genotox assay

Test Method Number: TM2010-08 (EU)
Short Name of TM: GGA
Responsible Organisation: EURL ECVAM - European Union
General Comments: Does not qualify for entering validation
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Two-tiered approach to determine the skin sensitising capacity and potency of chemicals

Test Method Number: TM2011-12 (EU)
Short Name of TM: 2-TA
Responsible Organisation: EURL ECVAM - European Union
General Comments: Submission closed because an improved version of the test method has been submitted under TM2012-05
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards