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Automated screening to detect cardiotoxicity in zebrafish

Topic : Cardiotoxicity

Test Method Number: TM2009-07 (EU)
Short Name of TM: Zebrafish assay
Submission received on: July, 2009
Responsible Organisation: EURL ECVAM - European Union
Stage of Submission: Assessment of Pre-submission
General Comments:

On hold-pending further information

Method Description

Zebrafish embryos (48hpf) are exposed in a HTS system to test compounds and effects on heart rate, arrhythmia and death/fibrilation are automatically detected.

The aim of the method is to identify compounds that induce arrhythmia and consequently present a potential risk of QT interval prolongation. In addition, compounds that induce non zERG-related cardiotoxicity should be identified, to be classified as generally cardiotoxic.

The test is inteneded as screening method to detect cardiotoxicity of products in early stages of drug development.

Track Approval Status

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    Regulatory acceptance/Standards
In progressSubmissionShow status
 Regulatory acceptance/Standards