TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE
TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

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Thyroid method 5a: Inhibition of monocarboxylate transporter 8 (MCT8) based on Sandell-Kolthoff reaction
TM Status: Open
Test Method Number: TM2019-13 (EU)
Short Name of TM: MCT8-TR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 4c: Inhibition of THs sulfation using liquid chromatography
TM Status: Open
Test Method Number: TM2019-12 (EU)
Short Name of TM: THSUL-LC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 3b: Thyroxine-binding prealbumin (TTR) binding using fluorescence displacement (T4-FITC)
TM Status: Open
Test Method Number: TM2019-09 (EU)
Short Name of TM: T4-FITC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 3a: Thyroxine-binding prealbumin (TTR) / thyroxine-binding globulin (TBG) binding using fluorescence displacement (ANSA)
TM Status: Open
Test Method Number: TM2019-08 (EU)
Short Name of TM: ANSA-FD
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
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    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 2d: Activation of the sodium iodide symporter (NIS) based on Sandell-Kolthoff reaction
TM Status: Open
Test Method Number: TM2019-07 (EU)
Short Name of TM: NIS-SKR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
  •  
    Validation
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    Peer-review
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    Recommendation
  •  
    Regulatory acceptance/Standards