TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

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Two-tiered approach to determine the skin sensitising capacity and potency of chemicals
TM Status: Closed
Test Method Number: TM2011-12 (EU)
Short Name of TM: 2-TA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Sensitisation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
In vitro BALB/c 3T3 Cell Transformation Assay
TM Status: Closed
Test Method Number: TM2004-07 (EU)
Short Name of TM: BALB/c 3T3 CTA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Carcinogenicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
The Colony Forming Unit-Granulocyte/Macrophage Assay for predicting acute neutropenia in humans
TM Status: Closed
Test Method Number: TM2000-01 (EU)
Short Name of TM: CFU-GM
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Acute toxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Human Reconstructed Corneal Epithelium (HCE) Eye Irritation test
TM Status: Closed
Test Method Number: TM2008-09 (EU)
Short Name of TM: SkinEthic HCE
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Automated screening to detect cardiotoxicity in zebrafish
TM Status: Closed
Test Method Number: TM2009-07 (EU)
Short Name of TM: Zebrafish assay
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Cardiotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Embryonic Stem Cell Test
TM Status: Closed
Test Method Number: TM1999-01 (EU)
Short Name of TM: EST
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
Embryotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Micromass Embryotoxicity Assay
TM Status: Closed
Test Method Number: TM1999-02 (EU)
Short Name of TM: MM
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
Embryotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Postimplantation Rat Whole-Embryo Culture Assay
TM Status: Closed
Test Method Number: TM1999-03 (EU)
Short Name of TM: WEC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
Embryotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
In vitro production of monoclonal antibodies (hybridoma technique)
TM Status: Closed
Test Method Number: TM1998-04 (EU)
Short Name of TM: In vitro mAbs
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Human health
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Cytochrome P450 (CYP) enzyme induction in vitro method using the cryopreserved human hepatocytes
TM Status: Closed
Test Method Number: TM2009-13 (EU)
Short Name of TM: CryoHeps
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Toxicokinetics
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards