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Results: 21 - 30 of 66

THOR VitroDerm RhE test method for skin irritation testing

Test Method Number: TM2009-10 (EU)
Short Name of TM: VitroDerm
Topic(s): Skin irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Chorioallantoic membrane vascular assay

Test Method Number: TM2008-06 (EU)
Short Name of TM: CAMVA
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information (under external validation)
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Waring test for endocrine disruptor identification

Test Method Number: TM2008-07 (EU)
Short Name of TM: Waring test
Topic(s): Reproductive toxicity - Endocrine disruption
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
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    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Bovine Oocyte Maturation Assay

Test Method Number: TM2010-05 (EU)
Short Name of TM: IVM
Topic(s): Reproductive toxicity - In vitro fertilisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
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    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The LUMI-CELL® ER Test Method: An In Vitro Assay for Identifying Human Estrogen Receptor Agonist and Antagonist Activity of Chemicals

Test Method Number: TM2016-03 (US)
Short Name of TM: VM7Luc ER TA assay
Topic(s): Reproductive toxicity - Endocrine disruption
Responsible Organisation: ICCVAM/NICEATM - United States
General Comments: This test method was originally referred to as the BG1Luc ER TA method. In June 2016, NICEATM received new information regarding the BG1Luc estrogen receptor (ER) transactivation (LUMI-CELL®) assay (TA). DNA testing has now shown that the original cell line used to develop the assay was not the BG1 human ovarian carcinoma cell line, but was instead a variant of the MCF7 human breast cancer cell line. The cell line used in the assay, originally referred to as BG1Luc4E2 (Rogers and Denison, 2000), will now be designated as VM7Luc4E2 (“V” = variant; “M7” = MCF7 cells). Likewise, the assay will now be designated as the VM7Luc ER TA. While this changes the origin of the cell line upon which the assay is based, it does not affect published validation studies nor the utility and application of this assay for screening of estrogenic/anti-estrogenic chemicals.
Stage of Submission: Assessment Finalised
Stage of Validation: Finalised
Stage of Peer-review: Finalised
Stage of Recommendation: Published
Stage of Regulatory acceptance/Standards: Adopted
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    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Transepithelial permeability assessment using an in vitro cell model of the human airway epithelium

Test Method Number: TM2014-03 (EU)
Short Name of TM: MucilAir
Topic(s): Respiratory permeability/penetration, toxicokinetics
Responsible Organisation: EURL ECVAM - European Union
General Comments: Considered to be followed up in the wider context of ADME methods
Stage of Submission: Not considered for validation
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    Submission
  • 2
    Validation
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    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

EpiOcular™ Human Cell Construct EIT

Test Method Number: TM2008-10 (EU)
Short Name of TM: EpiOcular EIT
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
Stage of Submission: Assessment Finalised
Stage of Validation: Finalised
Stage of Peer-review: Finalised
Stage of Recommendation: Drafting
Stage of Regulatory acceptance/Standards: Published
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Transcriptomics based Genomics-Genotox assay

Test Method Number: TM2010-08 (EU)
Short Name of TM: GGA
Topic(s): Genotoxicity
Responsible Organisation: EURL ECVAM - European Union
General Comments: Does not qualify for entering validation
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Monocyte Activation Test

Test Method Number: TM2016-06 (BRA)
Short Name of TM: MAT
Topic(s): Quality control of vaccines, Airborne pyrogens
Responsible Organisation: BraCVAM - Brazil
Stage of Validation: Ongoing
Stage of Regulatory acceptance/Standards: Drafting of new regulatory standard/guideline
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    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

A new in vitro eye irritation test with a 3D-reconstructed human cornea epithelium, MCTT HCE™

Test Method Number: TM2016-04 (KOR)
Short Name of TM: MCTT HCE™-EIT
Topic(s): Eye irritation
Responsible Organisation: KoCVAM - Republic of Korea
Stage of Submission: Assessment Finalised
Stage of Validation: Ongoing
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards