TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

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Thyroid method 8c: In vitro human adipose stromal cell—human umbilical vein endothelial cell (hASC-HUVEC) vasculogenesis/angiogenesis method
TM Status: Open
Test Method Number: TM2019-19 (EU)
Short Name of TM: VAAN-hadum
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Thyroid method 8b: Proliferation, migration and oligodendrocyte maturation (including myelin formation) in mixed neuronal/glial culture (neurospheres) derived from human induced Pluripotent Stem Cells (hiPSC)
TM Status: Open
Test Method Number: TM2019-18 (EU)
Short Name of TM: PMOD-hNPC
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
SENS-IS
TM Status: Closed
Test Method Number: TM2011-11 (EU)
Short Name of TM: SENS-IS
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Transactivation assay for detection of androgenic activity of chemicals
TM Status: Closed
Test Method Number: TM2010-07 (EU)
Short Name of TM: AR-CALUX
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Reproductive toxicity,
Endocrine disruption
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
ProtReact
TM Status: Closed
Test Method Number: TM2022-01 (EU)
Short Name of TM: ProtReact
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin sensitisation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
LUCS (Light-up Cell System)-VALITOX
TM Status: Closed
Test Method Number: TM2021-01 (EU)
Short Name of TM: LUCS-VALITOX
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Acute toxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Genomic Allergen Rapid Detection test
TM Status: Open
Test Method Number: TM2011-09 (EU)
Short Name of TM: GARD
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Sensitisation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Skin Irritation Test for the Prediction of Acute Skin Irritation of Chemicals With Sterlab RHE: 42 minutes application + 42 hours post-incubation
TM Status: Open
Test Method Number: TM2014-06 (EU)
Short Name of TM: Sterlab RHE SIT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Skin irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Cytochrome P450 (CYP) enzyme induction in vitro method using cryopreserved differentiated human HepaRG™ cells
TM Status: Open
Test Method Number: TM2009-14 (EU)
Short Name of TM: HepaRG™
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Toxicokinetics
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Human 3-D Epidermis Model in Vitro Phototoxicity Test
TM Status: Open
Test Method Number: TM1997-02 (EU)
Short Name of TM: EpiDerm-PT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Basal Cytotoxicity
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards