TRACKING SYSTEM FOR ALTERNATIVE METHODS TOWARDS REGULATORY ACCEPTANCE

TSAR indicates the stages methods have reached in terms of acceptance as a recognised test method for use in various sectors together with a summary description. Where available, TSAR also includes relevant records and documents associated with a method linked to the different steps of the entire process: submission, validation, peer-review, recommendations and regulatory acceptance including international standards represented in the tracking system.

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Thyroid method 5a: Inhibition of monocarboxylate transporter 8 (MCT8) based on Sandell-Kolthoff reaction
TM Status: Open
Test Method Number: TM2019-13 (EU)
Short Name of TM: MCT8-TR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
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    Validation
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    Peer-review
  •  
    Recommendation
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    Regulatory acceptance/Standards
Thyroid method 1a: PATHHUNTER® BETA-ARRESTIN thyrotropin-releasing hormone (TRH) receptor activation (beta-galactosidase) measuring agonist and antagonist activities
TM Status: Open
Test Method Number: TM2019-02 (EU)
Short Name of TM: TRH-CHOK1
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Thyroid method 7a: Measurement of intrafollicular thyroxine (T4) using zebrafish eleutheroembryos
TM Status: Open
Test Method Number: TM2019-16 (EU)
Short Name of TM: ZETA
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Thyroid method 2d: Activation of the sodium iodide symporter (NIS) based on Sandell-Kolthoff reaction
TM Status: Open
Test Method Number: TM2019-07 (EU)
Short Name of TM: NIS-SKR
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Endocrine disruption
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Cytochrome P450 (CYP) enzyme induction in vitro method using cryopreserved differentiated human HepaRG™ cells
TM Status: Open
Test Method Number: TM2009-14 (EU)
Short Name of TM: HepaRG™
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Toxicokinetics
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    Submission
  •  
    Validation
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    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Human 3-D Epidermis Model in Vitro Phototoxicity Test
TM Status: Open
Test Method Number: TM1997-02 (EU)
Short Name of TM: EpiDerm-PT
Responsible Organisation: EURL ECVAM - European Union 
Topic(s): Basal Cytotoxicity
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    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Bovine corneal opacity and permeability test method
TM Status: Closed
Test Method Number: TM2003-03 (US)
Short Name of TM: BCOP
Responsible Organisation: ICCVAM/NICEATM - United States 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Isolated Chicken Eye
TM Status: Closed
Test Method Number: TM2003-02 (US)
Short Name of TM: ICE
Responsible Organisation: ICCVAM/NICEATM - United States 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Short Time Exposure Test
TM Status: Closed
Test Method Number: TM2008-15 (US)
Short Name of TM: STE
Responsible Organisation: ICCVAM/NICEATM - United States 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards
Antimicrobial Cleaning Product Testing Strategy
TM Status: Closed
Test Method Number: TM2008-16 (US)
Short Name of TM: Antimicrobial Cleaning Product Testing Strategy
Responsible Organisation: ICCVAM/NICEATM - United States 
Topic(s): Serious eye damage/Eye irritation
  •  
    Submission
  •  
    Validation
  •  
    Peer-review
  •  
    Recommendation
  •  
    Regulatory acceptance/Standards