Legal Notice
European Commission
JRC
IHCP
TSAR
TSAR
:
T
racking
S
ystem for
A
lternative test methods Review, Validation and Approval in the Context of EU
R
egulations on Chemicals
The Process
+
Review and Validation
Method submission
Regulatory relevance assessment
Pre-validation
Validation
Peer Review
Validation statement
Post-validation
+
Regulatory Approval
Stage 1: Technical Discussions with EU Experts
Stage 2: Technical conclusion and proposal agreement
Stage 3: Draft Proposal consultation
Stage 4: Final Proposal and adoption
Validation of  Methods
Approval of  Methods
+
Skin irritation and Corrosion
TER - Corrosion
HSM - Corrosion
CORROSITEX - Corrosion
EPISKIN - Irritation
EPIDERM - Irritation
Modified EpiDerm
SkinEthic
+
Eye Irritation
BCOP
ICE
RRET, IRE
HET-CAM
FL
LVET
+
Skin Sensitisation
LLNA
rLLNA
+
Mutagenicity
Micronucleus
+
Acute Systemic Toxicity
FDP
ATC
Up and Down
Acute Inhalation Toxicity
ATC Inhalation
+
Repeated Dose Toxicity
Not available
+
Reproductive Toxicity
EST
MM
WET
+
Other
3T3NRU Phototoxicity
Skin absorption
STTA for EDs
+
Acute Toxicity to Fish
FTA
Review and Validation
Method submission
An alternative method is submitted to ECVAM for its review in terms of applicability in the regulatory context and readiness to enter the validation process.
For more information:
European Centre for the Validation of Alternative Methods (ECVAM)