TSAR : Tracking System for Alternative test methods Review, Validation and Approval in the Context of EU Regulations on Chemicals

Other
Stably Transfected Human Estrogen Receptor-alpha Transcriptional Activation Assay for Detection of Estrogenic Agonist-Activity of Chemicals (STTA)
3 Rs Category :  Reduction/Replacement
Type of Method :  In vitro
Validation Statement :  None
Comment :  To be ventually used within a testing strategyfor EDs.
Provides mechanistic information.
Validation study by the Japanese Chemicals Evaluation and Research Institute (CERI)demonstrated the relevance and reliability of the assay for its intended purpose.
Status of adoption in EU :  Foreseen for 3rd adaptation to technical progress (ATP) of Reg 440/2008.
Beginning of 2010.
Stage 3.
Corresponding OECD TG :  TG 436.
Adopted 7 September 2009.
Status of adoption by OECD :  OECD