| European CommissionJRCIHCPTSAR |
| Reproductive Toxicity |
| Micromass Embryotoxicity Assay (MM) |
| 3 Rs Category | : | Refinement |
| Type of Method | : | In vitro |
| Validation Statement | : | 01/05/2002 |
| Comment | : | Need to sacrifice parents. Uses embryos. Covers only partially the reprotox endpoint. Currently have limited value due to limited number and range of substances tested and absence of a biotransformation system, it can have a role, when considered alongside other data, in a Weight of Evidence assessment and in support of read-across approaches, and can serve as a trigger for further testing. Already mentioned in REACH Guidance on "Information Requirements and Chemical Safety Assessment" (May 2008) ECHA |
| Status of adoption in EU | : | Not in EU Regulation. Not foreseen until comprehensive valid testing strategy for the endpoint is available. Being addressed in some EU research projects. Currently, its general application would increase animal use. |
| 1st Published in EC Regulations/ Updates | : | Not foreseen |
| Reconducted to TMR (updated when appropriate) | : | Not foreseen |
| Corresponding OECD TG | : | None |
| Status of adoption by OECD | : | Not included and not foreseen yet. No OECD activity. |