| European CommissionJRCIHCPTSAR |
| Reproductive Toxicity |
| Embryonic Stem Cell Test for Embryotoxicity (EST) |
| 3 Rs Category | : | In vitro |
| Type of Method | : | Partial Replacement |
| Validation Statement | : | 01/05/2002 |
| Comment | : | Covers only partially the reprotox endpoint. Currently has limited value due to limited number and range of substances tested and absence of a biotransformation system, it can have a role, when considered alongside other data, in a Weight of Evidence assessment and in support of read-across approaches, and can serve as a trigger for further testing. Already mentioned in REACH Guidance on "Information Requirements and Chemical Safety Assessment" (May 2008) ECHA |
| Status of adoption in EU | : | Not in EU Regulation. Not foreseen until comprehensive valid testing strategy for the endpoint is available. Being addressed in some EU research projects. Possible use as screening tool in R&D. |
| 1st Published in EC Regulations/ Updates | : | Not foreseen. |
| Reconducted to TMR (updated when appropriate) | : | Not foreseen. |
| Status of adoption by OECD | : | Not included and not foreseen yet. No OECD activity. |