| European CommissionJRCIHCPTSAR |
| Acute Systemic Toxicity |
| Up and Down Method |
| 3 Rs Category | : | Reduction |
| Type of Method | : | In vivo |
| Validation Statement | : | 31/10/2007. ESAC retrospective statements were issued due to formal needs under the Cosmetics Directive. |
| Comment | : | Replaces the old B.1 method on acute oral toxicity (the LD50 method) which was DELETED in Dir 2001/59/EC (Official Journal L 225 2001). Already mentioned in REACH Guidance on "Information Requirements and Chemical Safety Assessment" (May 2008) ECHA |
| Status of adoption in EU | : | Not included in the EU regulations. Not considered high priority as two other alternative methods exist and the results obtained with OECD TG 425 are anyway accepted in the EU due to OECD MAD agreement. Being considered for a forthcoming adaptation of the TMR. Stage 3. |
| Corresponding OECD TG | : | TG 425 Acute oral toxicity; Up and Down Method (UDM) |
| Status of adoption by OECD | : | OECD |