TSAR (Tracking System for Alternative test methods Review Validation and Approval in the Context of EU Regulations on Chemicals).

European Commission JRC IHCP TSAR

TSAR : Tracking System for Alternative test methods Review, Validation and Approval in the Context of EU Regulations on Chemicals

+ Review and Validation

Method submission

Regulatory relevance assessment

Validation statement

Post-validation

+ Regulatory Approval

Stage 1: Technical Discussions with EU Experts

Stage 2: Technical conclusion and proposal agreement

Stage 3: Draft Proposal consultation

Stage 4: Final Proposal and adoption

Validation of Methods

Approval of Methods

+ Skin irritation and Corrosion

TER - Corrosion

HSM - Corrosion

CORROSITEX - Corrosion

EPISKIN - Irritation

EPIDERM - Irritation

Modified EpiDerm

+ Eye Irritation

+ Skin Sensitisation

+ Acute Systemic Toxicity

Acute Inhalation Toxicity

+ Repeated Dose Toxicity

+ Reproductive Toxicity

3T3NRU Phototoxicity

Skin absorption

+ Acute Toxicity to Fish

Mutagenicity