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TSAR : Tracking System for Alternative test methods Review, Validation and Approval in the Context of EU Regulations on Chemicals

Eye Irritation
Hen's egg test - chorio-allantoic membrane (HET-CAM test).
HET-CAM
3 Rs Category :  Partial Replacement
Type of Method :  In vitro
Statement on scientific validity and
potential use
 :  ESAC (27/04/2007) recommended further work before validity can be fully assessed.
Comment :  Referenced in REACH Guidance on "Information Requirements and Chemical Safety Assessment" (May 2008) ECHA
Status of adoption in EU :  Positive results already accepted since 2002:
See in Manual of Decisions of the Competent Authorities MoD.
Formal adoption to be considered when additional information will be available.
Corresponding OECD TG :  None
Status of OECD adoption :  Not included and not foreseen yet.
No OECD activity.