| European CommissionJRCIHCPTSAR |
| Skin Sensitisation |
| reduced Local Lymph Node Assay (rLLNA) |
| 3 Rs Category | : | Reduction |
| Type of Method | : | In vivo |
| Validation Statement | : | 27/04/2007 |
| Comment | : | Serious concerns raised by EU MS Regulatory Authorities about low sensitivity, lack of information on potency, dose selection and possibility to actually increase animal use. Stopped in Stage 2. Already mentioned in REACH Guidance on "Information Requirements and Chemical Safety Assessment" (May 2008) ECHA |
| Status of adoption in EU | : | Not considered appropriate yet. To be reconsidered when more experience on its use is available. |
| Corresponding OECD TG | : | None |
| Status of adoption by OECD | : | In discussion. |