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| TSAR : Tracking System for Alternative test methods Review, Validation and Approval in the Context of EU Regulations on Chemicals |
| Skin Sensitisation |
| B.42 Skin Sensitisation: Local Lymph Node Assay (LLNA) |
| 3 Rs Category | : | Reduction and refinement |
| Type of Method | : | In vivo |
| Validation Statement | : | 21/03/1999 |
| Comment | : | Reduces number of test animals and uses less aggressive procedure. |
| Status of adoption in EU | : | Adopted in 2004. |
| 1st Published in EC Regulations/ Updates | : | Directive 2004/73/EC (Official Journal L 152 2004) |
| Reconducted to TMR (updated when appropriate) | : | Regulation 440/2008/EC (Official Journal L 142 2008) |
| Text of EU method | : | B.42 |
| Corresponding OECD TG | : | TG 429.
Update on-going to add two non-radioactive version and perfomance standards. |
| Status of adoption by OECD | : | OECD |
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