| European CommissionJRCIHCPTSAR |
| Eye Irritation |
| Isolated rabbit enucleated eye test (REET, IRE) |
| 3 Rs Category | : | Replacement |
| Type of Method | : | In vitro |
| Validation Statement | : | ESAC (27/04/2007) recommended further work before validity can be fully assessed. |
| Comment | : | Uses ("ex-vivo") organ from animals slaughtered for food industry or from sacrificed animals. Already mentioned in REACH Guidance on "Information Requirements and Chemical Safety Assessment" (May 2008) ECHA |
| Status of adoption in EU | : | Positive results already accepted since 2002: See in Manual of Decisions of the Competent Authorities MoD. Formal adoption to be considered when additional information will be available. |
| Corresponding OECD TG | : | None |
| Status of adoption by OECD | : | Not included and not foreseen yet. No OECD activity. |