TSAR (Tracking System for Alternative test methods Review Validation and Approval in the Context of EU Regulations on Chemicals).

TSAR : Tracking System for Alternative test methods Review, Validation and Approval in the Context of EU Regulations on Chemicals

Skin irritation and Corrosion

B.40 Skin Corrosion: Transcutaneous Electrical Resistance (TER)

3 Rs Category	:	Replacement
Type of Method	:	In vitro
Validation Statement	:	Scientific validity of test method (ESAC): 03/04/1998.
Comment	:	To be used in the frame of a testing strategy for corrosion/irritation. Replaces classical test but still uses ("ex-vivo") organ from sacrificed animal.
Status of adoption in EU	:	Initiated in second half 1999 due to delay in OECD. Adopted in 2000.
1st Published in EC Regulations/ Updates	:	Directive 2000/33/EC (Official Journal L 136 2000).
Reconducted to TMR (updated when appropriate)	:	Regulation 440/2008/EC (Official Journal L 142 2008).
Text of EU method	:	B.40
Corresponding OECD TG	:	TG 430
Status of adoption by OECD	:	OECD