Navigation path

The Electrophilic Allergen Screening Assay for the Detection of Substances Causing Allergic Contact Dermatitis

Test Method Number: TM2016-01 (US)
Short Name of TM: EASA
Topic(s): Skin sensitisation
Responsible Organisation: ICCVAM/NICEATM - United States
Stage of Submission: Assessment Finalised
Stage of Validation: Planning
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Skin Sensitizer Predictor

Test Method Number: TM2013-03 (EU)
Short Name of TM: SS Predictor
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Not considered for follow-up
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Myeloid U937 Skin Sensitisation Test

Test Method Number: TM2013-02 (EU)
Short Name of TM: U-SENS™
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: The U-SENS™ test method was formely called Myeloid U937 Skin Sensitisation Test (MUSST) (TM 2009-05).
Stage of Submission: Assessment of Revised full submission
Stage of Validation: Finalised
Stage of Peer-review: Finalised
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

RHE IL-18 potency test for skin sensitization

Test Method Number: TM2012-05 (EU)
Short Name of TM: RHE IL-18
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Invitation to send a full submission
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

In vitro sensitisation testing strategy

Test Method Number: TM2011-14 (EU)
Short Name of TM: In vitro STS
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Not considered for follow-up, skin sensitisation IATAs are currently being addressed in the OECD Task Force on Hazard Assessment
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

SENS-IS

Test Method Number: TM2011-11 (EU)
Short Name of TM: SENS-IS
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Under external validation
Stage of Submission: Assessment Finalised
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

LuSens Assay

Test Method Number: TM2011-10 (EU)
Short Name of TM: LuSens
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: The Lu-Sens underwent an external catch-up validation study based on the performance standards for in vitro skin sensitisation ARE-NrF2 luciferase test methods (OECD 2015).
Stage of Submission: Assessment Finalised
Stage of Peer-review: Finalised
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

In vitro Method for Identifying Skin Sensitisers Combining Peptide Binding with ARE/EpRE Mediated Gene Expression in Human Skin Cells

Test Method Number: TM2011-02 (EU)
Short Name of TM: SenCeetox
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Direct Peptide Reactivity Assay

Test Method Number: TM2009-06 (EU)
Short Name of TM: DPRA
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Validation finalised, ECVAM Recommendation published, OECD TG available
Stage of Submission: Assessment Finalised
Stage of Validation: Finalised
Stage of Peer-review: Finalised
Stage of Recommendation: Published
Stage of Regulatory acceptance/Standards: Published
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Myeloid U937 Skin Sensitisation Test

Test Method Number: TM2009-05 (EU)
Short Name of TM: MUSST
Topic(s): Skin sensitisation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Validation stopped. New submission with new protocol received under TM2013-02 (U-Sens)
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards
tutorial