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Hen’s Egg Test – Chorio-Allantoic Membrane

Test Method Number: TM2016-05 (BRA)
Short Name of TM: HET-CAM
Topic(s): Eye irritation
Responsible Organisation: BraCVAM - Brazil
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

A new in vitro eye irritation test with a 3D-reconstructed human cornea epithelium, MCTT HCE™

Test Method Number: TM2016-04 (KOR)
Short Name of TM: MCTT HCE™-EIT
Topic(s): Eye irritation
Responsible Organisation: KoCVAM - Republic of Korea
Stage of Submission: Assessment Finalised
Stage of Validation: Ongoing
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

SkinEthic™ HCE Eye Irritation Test

Test Method Number: TM2015-03 (EU)
Short Name of TM: SkinEthic HCE EIT
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: External validation performed. Report submitted for peer-review as full test submission.
Stage of Submission: Not applicable
Stage of Validation: Finalised
Stage of Peer-review: Finalised
Stage of Recommendation: Drafting
Stage of Regulatory acceptance/Standards: Revision of existing regulatory standard/guideline
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

iPSC-derived corneal epithelial cells for ocular toxicity tests

Test Method Number: TM2014-07 (EU)
Short Name of TM: CORNiPSC
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Not considered for follow-up
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The IMOLA-IVD test method for eye irritation testing

Test Method Number: TM2010-04 (EU)
Short Name of TM: IMOLA-IVD
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Chemical reactivity measurement using the gluthatione (GSH and GSSG) peptide binding HPLC assay

Test Method Number: TM2009-04 (EU)
Short Name of TM: GSH-GSSG
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Not prioritised for validation by ECVAM. In the context of the Cosmetics Europe/EURL ECVAM Eye Irritation Validation Study it was decided in April 2009 not to include the GSH/GSSG reactivity assay in the SkinEthicTM HCE test strategy.
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Chemical reactivity measurement using the cysteine or lysine peptide binding HPLC assay

Test Method Number: TM2009-03 (EU)
Short Name of TM: EPRA
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Validation performed in context of the Cosmetics Europe/EURL ECVAM Eye Irritation Validation Study in the scope of the validation of SkinEthic HCE (TM2008-09)
Stage of Submission: Assessment Finalised
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

The Irritection Assay System

Test Method Number: TM2009-01 (EU)
Short Name of TM: Ocular Irritection
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: Revised Test Submission Template on the Ocular Irritection® test method proposed for Peer Review
Stage of Submission: Assessment Finalised
Stage of Peer-review: Finalised
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Human Reconstructed Corneal Epithelium (HCE) Eye Irritation test

Test Method Number: TM2008-09 (EU)
Short Name of TM: SkinEthic HCE
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: This test method was unable to comply fully with the acceptance criteria set by the validation management group. A revised SkinEthic™ HCE EIT test method was re-submitted for assessment by EURL ECVAM and formal ESAC peer review in October 2015 (See TM2015-03, SkinEthic-HCE-EIT).
Stage of Submission: Not considered for validation
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards

Chorioallantoic membrane vascular assay

Test Method Number: TM2008-06 (EU)
Short Name of TM: CAMVA
Topic(s): Eye irritation
Responsible Organisation: EURL ECVAM - European Union
General Comments: On hold-pending further information (under external validation)
Stage of Submission: Assessment of Pre-submission
  • 1
    Submission
  • 2
    Validation
  • 3
    Peer-review
  • 4
    Recommendation
  • 5
    Regulatory acceptance/Standards
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